COMPOSITIONS AND METHODS OF TREATING FUNGAL AND BACTERIAL PATHOGENS
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Feb 4, 2016
app pub date -
Mar 14, 2014
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Mar 15, 2013
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The invention features isolated polypeptides and conjugates including the amino acid sequence of any one of SEQ ID NOs: 3-11, or a variant sequence thereof having up to three substitutions, deletions, or additions to the amino acid sequence of any one of SEQ ID NOs: 3-11, wherein the polypeptide does not include more than 20 contiguous amino acids of SEQ ID NO: 2 or SEQ ID NO: 17. Additional polypeptides includes those of formula (I) [ZNZPVSSBSFSYT]n and formula (II) [ZNUWOOBUFOYT]n. The invention further features vaccines including such polypeptides or conjugates and methods of vaccination against candidiasis or a staphylococcal infection of both using same. In addition, the invention features antibodies that bind to the polypeptides or conjugates, and methods of passive immunization using same.
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