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• 15 United States
• 10 France
• 8 Japan
• 7 China
• 5 Korea
• 2 Other

Patent Owner(s)

Patent Owner	Address
NOVEN PHARMACEUTICALS INC	11960 SOUTHWEST 144TH STREET MIAMI FL 33186

International Classification(s)

• A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
• C08F:MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONL....

• 2015 Application Filing Year
• A61K Class
• 16157 Applications Filed
• 11882 Patents Issued To-Date
• 73.55 % Issued To-Date

Inventor(s)

Inventor Name	Address	# of filed Patents	Total Citations
Dinh, Steven	Miami, US	50	393
# of filed Patents : 50 Total Citations : 393
Liao, Jun	Miami, US	101	588
# of filed Patents : 101 Total Citations : 588
Liu, Puchun	Miami, US	36	297
# of filed Patents : 36 Total Citations : 297
Zhang, Jilin	Miami, US	29	126
# of filed Patents : 29 Total Citations : 126

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Patent Citation Ranking

• 21 Citation Count
• A61K Class

• 96.87 % this patent is cited more than
• 9 Age

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Full Text

US Patent Application No: 2012/0128,649

MODIFIED NON-CYTOTOXIC PROTEASES

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Abstract

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The present invention relates to a modified polypeptide comprising a non-cytotoxic protease, a translocation domain, a destructive protease cleavage site and a Targeting Moiety that binds to a Binding Site on a nerve cell, wherein after cleavage of the destructive cleavage site the polypeptide has reduced potency. The destructive cleavage site is recognised and cleaved by a protease present at or in an off-site target cell, and, in one embodiment, the polypeptide is a modified clostridial neurotoxin. The present invention also relates to the use of said polypeptides for treating a range of conditions, and to nucleic acids encoding said polypeptides.

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Description

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