PREPARATION AND CHARACTERIZATION OF BONE-TARGETED VANCOMYCIN-LOADED LIPOSOMES FOR OSTEOMYELITIS TREATMENT
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United States of America Patent
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Issued Date -
Feb 4, 2016
app pub date -
Jul 31, 2015
filing date -
Aug 1, 2014
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Abstract
A treatment method, system, and compound comprise directly targets osteomyelitis-infected bone tissue with one or more surface-modified liposomes. The surface-modified liposome(s) includes an alendronate targeting moiety utilized to modify the surface of the liposome. Alendronate targets hydroxyapatite in bone tissue, wherein the surface-modified liposome further comprises encapsulated vancomycin that directly targets the hydroxyapatite in the infected bone tissue and prevents bone implant related infection.
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