METHODS OF SELECTING COMBINATION THERAPY FOR COLORECTAL CANCER PATIENTS
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United States of America Patent
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Jan 28, 2016
app pub date -
Jul 31, 2015
filing date -
Feb 5, 2013
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Abstract
The present invention provides methods for selecting a subject as suitable for combination therapy with EGFR and HER2 inhibitors. The present invention also provides methods for predicting whether a subject will benefit from the combination therapy. In some embodiments, the present invention provides methods for determining whether to administer a combination therapy in a subject receiving EGFR inhibitor therapy. In other embodiments, the present invention provides methods for monitoring a subject on EGFR inhibitor therapy to determine whether to administer a combination therapy of EGFR and HER2 inhibitors. The present invention is particularly useful to facilitate the design of personalized therapies for colorectal cancer patients with EGFR inhibitor sensitivity.
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