HYPOSIALYLATION DISORDERS
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United States of America Patent
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Jan 28, 2016
app pub date -
Mar 13, 2014
filing date -
Mar 14, 2013
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Abstract
Methods are disclosed for diagnosing a hyposialylation disorder. Methods are also disclosed for determining the effectiveness of a therapeutic agent for treatment of a hyposialylation disorder in a subject. These methods include measuring an amount of monosialylated Thomsen-Friedenreich (ST) antigen and measuring an amount of non-sialylated Thomsen-Friedenreich antigen (T) in a biological sample, such as a serum or plasma sample from the subject, and determining the ratio of T to ST.
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