INSULIN-INCRETIN CONJUGATES

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United States of America Patent

SERIAL NO

14774357

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Abstract

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Disclosed herein are insulin agonist peptides conjugated to incretins wherein the insulin/incretin conjugate has agonist activity at both the insulin receptor and the corresponding incretin receptor. Insulin is a proven therapy for the treatment of juvenile-onset diabetes and later-stage adult-onset diabetes. The peptide is biosynthesized as a larger linear precursor of low potency (approximately 2% to 9% of native insulin), named proinsulin. Proinsulin is proteolytically converted to insulin by the selective removal of a 35-residue connecting peptide (C peptide).

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Patent Owner(s)

Patent OwnerAddress
INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION351 W 10TH STREET INDIANAPOLIS IN 46202

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DIMARCHI, RICHARD D Carmel, US 132 3953
HAN, JIE BEIJING, CN 47 508
LI, PENGYUN Bloomington, US 8 20
PARODY, TODD Bloomington, US 5 7

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