TUBULYSIN COMPOUNDS AND CONJUGATES THEREOF
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United States of America Patent
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Jan 28, 2016
app pub date -
Mar 13, 2014
filing date -
Mar 14, 2013
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Abstract
A tubulysin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a tubulysin compound having a molecular weight≦5 kDa. LD and LP are distinct linkers connecting the tubulysin compound and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-tubulysin compound-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
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