Method of Labeling Flumazenil with F-18 and Separating and Purifying F-18-Flumazenil

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United States of America Patent

APP PUB NO 20160016958A1
SERIAL NO

14333630

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Abstract

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Flumazenil (FMZ) is labeled with fluorine(F)-18 to obtain F-18-flumazenil. F-18-flumazenil can be strongly combined with type-A acceptor of gamma-aminobutyric acid (GABAA) in brain for tracing. The time and temperature for labeling is saved and lowered. The toxic chemical, acetonitrile, used in separation and purification can be prevented. The present invention has a simplified procedure for evaluating mental disease medicines in a short time. Moreover, time for developing medicines for treating related diseases of the central nervous system can be reduced.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL EXECUTIVE YUAN R O CNO 1000 WUNHUA RD JIAAN VILLAGE LONGTAN DISTRICT TAOYUAN CITY

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  • 2014 Application Filing Year
  • C07D Class
  • 5203 Applications Filed
  • 4627 Patents Issued To-Date
  • 88.93 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Kang-Wei Taoyuan County, TW 10 18
Cheng, Kai-Hung Taoyuan County, TW 12 16
Huang, Li-Yuan Taoyuan County, TW 13 6
Huang, Yuan-Ruei Taoyuan County, TW 7 0
Tu, Yean-Hung Taoyuan County, TW 6 5

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges137619812528031834145701 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0100200300400500600700800900100011001200130014001500160017001800190020002100

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