Method of Labeling Flumazenil with F-18 and Separating and Purifying F-18-Flumazenil
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United States of America Patent
Stats
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N/A
Issued Date -
Jan 21, 2016
app pub date -
Jul 17, 2014
filing date -
Jul 17, 2014
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Flumazenil (FMZ) is labeled with fluorine(F)-18 to obtain F-18-flumazenil. F-18-flumazenil can be strongly combined with type-A acceptor of gamma-aminobutyric acid (GABAA) in brain for tracing. The time and temperature for labeling is saved and lowered. The toxic chemical, acetonitrile, used in separation and purification can be prevented. The present invention has a simplified procedure for evaluating mental disease medicines in a short time. Moreover, time for developing medicines for treating related diseases of the central nervous system can be reduced.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL EXECUTIVE YUAN R O C | NO 1000 WUNHUA RD JIAAN VILLAGE LONGTAN DISTRICT TAOYUAN CITY |
International Classification(s)

- 2014 Application Filing Year
- C07D Class
- 5203 Applications Filed
- 4627 Patents Issued To-Date
- 88.93 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Chang, Kang-Wei | Taoyuan County, TW | 10 | 18 |
# of filed Patents : 10 Total Citations : 18 | |||
Cheng, Kai-Hung | Taoyuan County, TW | 12 | 16 |
# of filed Patents : 12 Total Citations : 16 | |||
Huang, Li-Yuan | Taoyuan County, TW | 13 | 6 |
# of filed Patents : 13 Total Citations : 6 | |||
Huang, Yuan-Ruei | Taoyuan County, TW | 7 | 0 |
# of filed Patents : 7 Total Citations : 0 | |||
Tu, Yean-Hung | Taoyuan County, TW | 6 | 5 |
# of filed Patents : 6 Total Citations : 5 |
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Patent Citation Ranking
- 0 Citation Count
- C07D Class
- 0 % this patent is cited more than
- 9 Age
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jul 21, 2027 |
Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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