Exo Olefin-Containing Nuclear Transport Modulators and Uses Thereof

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United States of America Patent

APP PUB NO 20160016916A1
SERIAL NO

14777306

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ATTORNEY / AGENT: (SPONSORED)

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The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and, more particularly, to a compound represented by structural formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

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KARYOPHARM THERAPEUTICS INC85 WELLS AVENUE NEWTON MA 02459

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Daelemans, Dirk Ezemaal (Landen), BE 2 0
Dehaen, Wim Alfrons Heverlee, BE 1 0
Leen, Volker Kortenaken, BE 4 0
Sandanayaka, Vincent P Northboro, US 29 621
Shacham, Sharon Newton, US 70 1083
Shechter, Sharon Andover, US 49 806

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