POWDER FORMULATION COMPRISING THROMBIN AND FIBRINOGEN

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United States of America Patent

APP PUB NO 20160015792A1
SERIAL NO

14773212

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Abstract

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The invention relates to sterile powder compositions suitable for medical use comprising thrombin and fibrinogen, and to methods for producing the same, wherein the thrombin powder is produced from a liquid feedstock, wherein the feedstock comprises a solution or a suspension of thrombin, preferably a solution, wherein the powder is produced by removal of liquid by a process selected from aseptic spray drying or aseptic fluid bed drying, and wherein the powder resulting from removal of liquid from the feedstock exhibits at least 80% of the thrombin potency or activity of the liquid feedstock, and wherein the fibrinogen powder is produced by removal of liquid from a feedstock, wherein the feedstock comprises a solution or a suspension of fibrinogen, preferably a solution, by aseptic spray drying or aseptic fluid bed drying, and wherein said composition is packaged as a sterile final pharmaceutical product for medical use.

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Patent Owner(s)

Patent OwnerAddress
MALLINCKRODT PHARMA IP TRADING D A CDAMASTOWN INDUSTRIAL ESTATE MULHUDDART DUBLIN 15

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hendricus, van Pinxteren Laurens Adrianus Leiden, NL 2 18
Martyn, Glen Leiden, NL 11 98
Whitfield, Nicola Kim Leiden, NL 7 159

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