Preparation method for high-yield production of physiologically active polypeptide conjugate
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United States of America Patent
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May 26, 2020
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Jan 14, 2016
app pub date -
Mar 5, 2014
filing date -
Mar 5, 2013
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Abstract
A method for preparing a conjugate by linking a physiologically active polypeptide, a non-peptidyl polymer linker, and an immunoglobulin constant region via a covalent bond are disclosed. The method enables an efficient preparation of a physiologically active polypeptide conjugate, in which a salt is used in a coupling reaction to improve the problem of low production yield during preparation of the physiologically active polypeptide conjugate.
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