ORAL DELIVERY OF PROTEINS AND PEPTIDES
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United States of America Patent
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Issued Date -
Jan 14, 2016
app pub date -
Sep 25, 2015
filing date -
Apr 26, 2007
priority date (Note) -
Abandoned
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Abstract
Enteric coated capsules or tables for oral delivery of a protein, polypeptide or peptide drug, in particular for oral delivery of insulin, are provided, comprising microparticles of the protein, polypeptide or peptide drug, microparticles of a protease inhibitor and, optionally, microparticles of an absorption enhancer. The protease inhibit and the absorption enhancer may be together in the same microparticles. The microparticles of each component are embedded in an enteric polymer matrix. The enteric coated tablet or capsule of the invention enables fast release of the protein, polypeptide or peptide drug at different times at desired loci in the gastrointestinal tract.
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