METHOD AND APPARATUS OF AIDING DETECTION OF SURFACE ABNORMALITY IN THE OESOPHAGUS
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Feb 19, 2014
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Feb 21, 2013
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Abstract
The invention relates to a method of aiding detection of a surface abnormality in the oesophagus of a subject, wherein said surface abnormality is selected from the group consisting of low-grade dysplasia (LGD), high-grade dysplasia (HGD), asymptomatic oesophageal adenocarcinoma (OAC) and intra-mucosal cancer (IMC), the method comprising:
- a) providing a sample of cells from said subject, wherein said sample comprises cells collected from the surface of the subject's oesophagus;b) assaying said cells for at least two markers selected from (i) p53;(ii) c-Myc;(iii) AURKA or PLK1, preferably AURKA; and(iv) methylation of MyoD and Runx3;wherein detection of abnormal levels of at least two of said markers infers that the subject has an increased likelihood of a surface abnormality in the oesophagus. The invention also relates to certain kits, apparatus and uses.
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