PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY
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United States of America Patent
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Jun 4, 2015
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Mar 11, 2009
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Abstract
The invention provides novel prodrug compounds comprising a kinase inhibitor and a reductively-activated fragmenting aromatic nitroheterocycle or aromatic nitrocarbocycle trigger, where the compound carries a positive charge. In preferred embodiments, the compounds are of Formula I:
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