HIGH THROUGHPUT SCREENING OF AGENTS ON DOPAMINERGIC NEURONS
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United States of America Patent
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Issued Date -
Dec 31, 2015
app pub date -
Feb 12, 2014
filing date -
Feb 13, 2013
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Abstract
A method of determining whether an agent is a neuroeffector is disclosed. The method comprises:
- (a) labeling dopaminergic neurons which are comprised in a mixed population of cells with a fluorescent dopamine analog;(b) measuring a level of fluorescence in the mixed population of cells;(c) exposing the mixed population of cells to the agent;(d) remeasuring a level of fluorescence in the mixed population of cells, wherein a change in the level of fluorescence is indicative of the substance being a neuroeffector.
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