Stabilization of biomolecules by attachment of responsive polymers and sensors thereof
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United States of America Patent
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Oct 20, 2020
Grant Date -
Dec 31, 2015
app pub date -
Dec 23, 2014
filing date -
Jan 23, 2014
priority date (Note) -
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Abstract
The present invention provides a biomolecule conjugate having one or more functionalized biomolecules wherein the biomolecule is functionalized with one or more reactive sites, and at least one polymer capable of undergoing a polymer growth reaction, wherein the polymer is attached to at least one of the reactive sites of the functionalized biomolecule and wherein the polymer envelopes the functionalized biomolecule to form a reversible nanoparticle structure which protects the biomolecule by dynamically collapsing to preserve the biomolecule when an adverse environmental stimulus is present. A method of protecting a biomolecule from environmental conditions is also provided.
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