T7 RNA POLYMERASE VARIANTS AND METHODS OF USING THE SAME
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United States of America Patent
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Dec 31, 2015
app pub date -
Oct 29, 2012
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Oct 29, 2012
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Abstract
The present invention relates to T7 RNA polymerase variants with improved affinity for 2′-modified nucleotides compared to the wildtype as well as methods for their production and methods of using them. The present invention also relates to the 2′-modified RNA molecules produced according to the methods of the invention.
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