Method for refolding antibody, process for producing refolded antibody, refolded antibody, and uses thereof

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United States of America Patent

PATENT NO 9850316
SERIAL NO

14767373

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Abstract

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A method for refolding an antibody, a process for producing a refolded antibody, a refolded antibody, and uses thereof are provided. A method for refolding an antibody in a liquid phase comprises the steps of denaturing an inactive antibody binding directly or through a linker to a peptide, the peptide having an isoelectric point lower than the isoelectric point of the inactive antibody, and dispersing in a liquid phase the peptide-binding inactive antibody denatured in the step above. Also provided is a process for producing a refolded antibody.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY1 MATSUGASAKI HASHIKAMI-CHO SAKYO-KU KYOTO-SHI KYOTO 6068585 ?6068585

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fujiwara, Yusuke Kyoto, JP 110 937
Ishikawa, Yasuyuki Kyoto, JP 20 342
Kishimoto, Michimasa Kyoto, JP 9 90
Kumada, Yoichi Kyoto, JP 14 29

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