Norrin Mutant Polypeptides, Methods of Making and Uses Thereof
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United States of America Patent
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Issued Date -
Dec 31, 2015
app pub date -
Feb 20, 2014
filing date -
Feb 21, 2013
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Abstract
The present invention relates to Norrin mutant polypeptides that inhibit or reduce angiogenesis in various tissues. Methods for synthesizing recombinant Norrin and Norrin mutant polypeptides are provided. Methods of inhibiting or reducing aberrant angiogenesis comprise contacting a tissue undergoing aberrant angiogenesis with a composition comprising an isolated Norrin C mutant polypeptide.
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