TNF-ALPHA ANTIGEN-BINDING PROTEINS
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United States of America Patent
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Dec 24, 2015
app pub date -
Jan 22, 2014
filing date -
Jan 24, 2013
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Abstract
The present invention provides antigen binding proteins which bind specifically to TNF-alpha. For example novel variants of anti-TNF antibodies such as adalimumab which show increased binding to the FcRn receptor or increased half life compared to adalimumab. Also provided are compositions comprising the antigen binding proteins and uses of such compositions in treatment of disorders and disease.
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