RADIOLABELED QUINAZOLINE DERIVATIVES

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United States of America Patent

APP PUB NO 20150368230A1
SERIAL NO

14765042

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Novel radiotracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging are described. Specifically, the invention relates to 18F-labeled afatinib suitable as a PET or SPECT tracer for imaging epidermal growth factor receptor (EGFR, erbB1) and human epidermal growth factor receptor 2 (Her2, erbB2), to a precursor compound for use in its synthesis, to methods for the preparation 18F-labeled afatinib, as well as to the use thereof in in vivo diagnosis, tumor imaging or patient stratification on the basis of mutational status of EGFR (erbB1) and Her2 (erbB2).

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Patent Owner(s)

Patent OwnerAddress
BOEHRINGER INGELHEIM INTERNATIONAL GMBH55216 INGELHEIM AM RHEIN

International Classification(s)

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  • 2014 Application Filing Year
  • A61K Class
  • 14144 Applications Filed
  • 11600 Patents Issued To-Date
  • 82.02 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2014201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
NIESSEN, Heiko Biberach an der Riss, DE 2 71
POOT, Alex Johannes Vleuten, NL 1 0
SLOBBE, Paul Amstelveen, NL 1 0
VAN, DONGEN Augustinus Antonius Maria Silvester Utrecht, NL 8 60
WINDHORST, Albert Dirk Alphen aan den Rijn, NL 4 6

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges4055742610302931335621135761001 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0500100015002000250030003500400045005000550060006500700075008000

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