PHARMACEUTICAL COMPOSITIONS FOR ORAL TREATMENT OF DIABETES
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Jan 29, 2014
filing date -
Jan 29, 2013
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Abstract
The present invention relates to pharmaceutical compositions for oral delivery comprising at least two bioactive proteins associated with glucose metabolism, selected from the group consisting of insulin, proinsulin and C-Peptide in a delivery vehicle adapted for oral administration that provides portal delivery of bioactive proteins. The exemplary pharmaceutical compositions comprise an oil-based matrix comprising solid particulate matter suspended therein, wherein the particulate matter comprises a polysaccharide non-covalently associated with silica particles having a hydrophobic surface, wherein the polysaccharide and silica particles are non-covalently associated with the at least two bioactive proteins. The present invention further provides therapeutic uses of said pharmaceutical compositions.
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