Method for Differentiating Sepsis and Systemic Inflammatory Response Syndrome (SIRS)
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United States of America Patent
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Dec 17, 2015
app pub date -
Jan 28, 2014
filing date -
Jan 28, 2013
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Abstract
A method of characterizing sepsis in a subject involves determining an amount in a biological sample from the subject of each biomarker in a biomarker panel including at least two biomarkers; and calculating a risk index or sepsis probability score using the amounts of biomarkers in the biomarker panel. Exemplary biomarker panels include TNF-alpha, interleukin-6, interleukin-10, lipopolysaccharide binding protein, and C-reactive protein; IL-1beta, procalcitonin, absolute neutrophil count, and immature granulocyte count; and Interleukin-8, GM-CSF, MCP1, and INF-gamma. The method can further involve determining one or more clinical parameters about the subject, and calculating the risk index using the amounts of the biomarkers in the biomarker panel and the clinical parameters.
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