Cell-Based Assay for Neutralizing Antibodies
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United States of America Patent
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Issued Date -
Dec 10, 2015
app pub date -
Jun 28, 2013
filing date -
Jul 11, 2012
priority date (Note) -
Abandoned
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Abstract
The present disclosure relates to a method for detecting the presence of PDGF neutralizing antibodies in a serum sample, comprising contacting a population of cells with i) a serum sample, and ii) PDGF, wherein the cells comprise a PDGF receptor; and detecting an amount of a biomarker in the population of cells, wherein the biomarker indicates binding of the PDGF with the PDGF receptor. The present disclosure also relates to a method of determining the presence of PDGF neutralizing antibodies in a subject who has received or is currently receiving a treatment comprising PDGF.
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