Diagnosing IDH1 related subgroups and treatment of cancer
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United States of America Patent
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Aug 4, 2020
Grant Date -
Dec 10, 2015
app pub date -
Aug 14, 2015
filing date -
Dec 11, 2009
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Abstract
The invention relates to classification, diagnosis and treatment of cancers. In one embodiment, the present invention provides methods and kits that classify cancers into various subtypes based on expression patterns of AKT pathway components. In another embodiment, the present invention provides methods and kits that diagnose cancer subtypes by evaluating expression patterns of AKT pathway components. In still another embodiment, the present invention provides methods and kits that treat a cancer subtype by administering an alkylating agent or a PI3K/AKT/mTOR inhibitor to a patient. Cancers suitable with various embodiments of the invention include but are not limited to brain tumors, gliomas and GBM.
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