HUMAN IGG1 FC REGION VARIANTS AND USES THEREOF
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Dec 10, 2015
app pub date -
Jan 10, 2013
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Jan 10, 2013
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Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved complement-dependent cytotoxicity (CDC).
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