Chromatography Media For Purifying Vaccines And Viruses
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United States of America Patent
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Dec 10, 2015
app pub date -
Jan 3, 2014
filing date -
Jan 31, 2013
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Abstract
Adsorptive media for chromatography, particularly ionexchange chromatography, derived from a shaped fiber, useful for purifying viruses. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Surface pendant functional groups can be added that provides ion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of viruses, such as influenza.
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