Compositions and Methods for the Prevention and Treatment of Osteolysis and Osteoporosis
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United States of America Patent
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Dec 10, 2015
app pub date -
Jan 16, 2014
filing date -
Jan 16, 2013
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This application discloses compositions, devices, and methods for the prevention and treatment of osteolysis and osteoporosis. Treatment or prevention of osteolysis or osteoporosis is carried out by targeting the enzyme, Shp2 (a Src homology 2 (SH2) domain containing non-transmembrane Protein Tyrosine Phosphatase (PTP)), or proteins involved in the Shp2 signaling pathway by administering a Shp2 pathway inhibitor that inhibits fusion of pre-osteoclasts.
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