MEK Mutations Conferring Resistance to MEK Inhibitors
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United States of America Patent
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Issued Date -
Dec 3, 2015
app pub date -
Jun 10, 2015
filing date -
Dec 10, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of MEK. In particular embodiments, the invention concerns mutations in a MEK sequence that confer resistance to a MEK inhibitor. Identification of such mutations in a MEK sequence allows the identification and design of second-generation MEK inhibitors. Methods and kits for detecting the presence of a mutant MEK sequence in a sample are also provided.
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