VACCINE FOR HPV INFECTION AND/OR HEPATITIS B COMPRISING HPV/HBS CHIMERIC PROTEIN AS ACTIVE INGREDIENT
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United States of America Patent
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Issued Date -
Dec 3, 2015
app pub date -
Nov 28, 2013
filing date -
Dec 25, 2012
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Abstract
A chimeric protein of HPV-L2 peptide and HBs protein wherein the HPV-L2 peptide is (1) a peptide consisting of the core sequence region of 20 amino acid residues, (2) a peptide inside the core sequence region comprising 6 amino acid residues Gly-Gly-Leu-Gly-Ile-Gly or (3) a peptide consisting of 70 or less amino acid residues obtained by adding an amino acid sequence derived from HPV L2 protein at the N-terminal and/or the C-terminal of the core sequence region; and a vaccine for HPV infection and/or hepatitis B comprising the chimeric protein as an active ingredient. A vaccine comprising the chimeric protein of the present invention is the one that has an increased expression level in a host, an enhanced immune ability (early antibody induction) and a broader spectrum effective for a number of HPV types.
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