Method of inhibiting ABCG2 and related treatments

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United States of America Patent

PATENT NO 9937217
SERIAL NO

14822437

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Abstract

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Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESBETHESDA MD 20892-7788

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ambudkar, Suresh V Gaithersburg, US 4 6
Bates, Susan E Bethesda, US 18 53
Bokesch, Heidi R Frederick, US 6 6
Dean, Michael C Frederick, US 17 126
Henrich, Curtis J Rockville, US 7 13
McMahon, James B Frederick, US 27 114
Robey, Robert W Laurel, US 5 6
Shukla, Suneet Rockville, US 4 6

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