COMPOSITION FOR DIAGNOSIS OF LUNG CANCER AND DIAGNOSIS KIT FOR LUNG CANCER
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United States of America Patent
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app pub date -
Aug 3, 2015
filing date -
Feb 28, 2013
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Abstract
A method of diagnosing small cell lung cancer comprises: measuring an expression level of serum paraoxonase 1 protein and a fucosylation level of the serum paraoxonase 1 protein in a biological sample from a small cell lung cancer patient and in a same biological sample from a normal person, and determining the expression level of the serum paraoxonase 1 protein is decreased in the biological sample of the small cell lung cancer patient as compared to the biological sample of a normal person, and the fucosylation level of the serum paraoxonase 1 protein is increased in the biological sample of the small cell lung cancer patient as compared to the biological sample of a normal person. The measuring of the fucosylation of the serum paraoxonase 1 protein comprises using a biotinylated lectin which binds specifically to fucose on the serum paraoxonase 1 protein and HRP-conjugated streptavidin in a hybrid ELISA.
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