Method for in vitro detection and monitoring of a disease by measuring disease-associated protease activity in extracellular vesicles
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United States of America Patent
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Dec 1, 2020
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Nov 26, 2015
app pub date -
Jan 9, 2014
filing date -
Jan 9, 2013
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Abstract
The present invention relates to a method for in vitro detection and/or monitoring of a disease in a sample, based on measurement of enzymatic activity of proteases activated and secreted upon disease development, to modified peptides used for the enzymatic detection of the proteases, the use of the peptides, a kit comprising such peptides and the use of ADAM-protease activity as a surrogate marker for disease burden and activity in infectious, inflammatory, and malignant diseases, such as HIV infection and melanoma.
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