ErbB-2 RECEPTOR TARGETING PEPTIDE

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United States of America Patent

APP PUB NO 20150335768A1
SERIAL NO

14728500

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The ErbB-2 receptor, a member of the tyrosine kinase type 1 family of receptors, has been implicated in many human malignancies. Bacteriophage display technology was employed to identify peptides that bound to the extracellular domain of human ErbB-2. The peptide KCCYSL, most frequently occurring in the affinity selected population, was chemically synthesized and characterized for its binding activities to the recombinant extracellular domain of ErbB-2. The synthetic peptide exhibits high specificity to ErbB-2 as well as to ErbB-1, another member of ErbB family. Thus, this peptide can be employed in cancer imaging or therapeutic agent targeting to malignant cells ErbB-2 receptor.

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Patent OwnerAddress
THE CURATORS OF THE UNIVERSITY OF MISSOURI316 UNIVERSITY HALL COLUMBIA MO 65211

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
KARASSEVA, Natalia G Columbia, US 3 1
QUINN, Thomas P Columbia, US 18 113

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