MODULATION OF MYOFIBER REPAIR BY ANTI-MYOSTATIN STRATEGIES AND/OR PPAR GAMMA LIGANDS, ALONE OR IN COMBINATION WITH STEM CELLS, FOR THE THERAPY OF CRITICAL LIMB ISCHEMIA AND OTHER ISCHEMIC PROCESSES AFFECTING THE SKELETAL MUSCLE
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United States of America Patent
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Nov 19, 2015
app pub date -
Dec 11, 2013
filing date -
Dec 11, 2012
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Treating or inhibiting an ischemic condition affecting the skeletal muscle comprising administering an agent having a property to inhibit an activity or a protein expression of myostatin or growth differentiation factor 8 (GDF-8) according to a regimen to treat or inhibit the ischemic condition. Treating or inhibiting an ischemic condition affecting the skeletal muscle including administering an effective amount of a thiazolidenedione or other PPAR gamma agonist at a dosage that do not exert glycemic control or induce overweight. A kit for use in treating or inhibiting an ischemic condition affecting the skeletal muscle comprising a quantity of an agent having a property to inhibit an activity or a protein expression of myostatin or growth differentiation factor 8 (GDF-8) and/or a quantity of a thiazolidenedione or other PPAR gamma agonist and instructions for administration of a dosage of that quantity according to a long term continuous regimen.
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