-acylated derivative of hyaluronic acid and method of preparation thereof
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United States of America Patent
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Jun 19, 2018
Issued Date -
N/A
app pub date -
Nov 26, 2013
filing date -
Nov 27, 2012
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication. Hyaluronic nanomicelles support the penetration of bound substances in topical applications and enable the bound substances to be transferred into the individual cells. The nanomicelles obtained from hydrophobized hyaluronan derivatives are usable in cosmetic and pharmaceutical applications.
First Claim
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Family
| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| CZ | B6 | CZ304654 | Nov 27, 2012 |
| JP | A | JP2016500130 | Nov 26, 2013 |
| KR | B1 | KR102191353 | Nov 26, 2013 |
| EP | B1 | EP2934592 | Nov 26, 2013 |
| RU | C2 | RU2640287 | Nov 26, 2013 |
| WO | A1 | WO2014082609 | Nov 26, 2013 |
| BR | A2 | BR112015012191 | Nov 26, 2013 |
International Classification(s)
- 2013 Application Filing Year
- A61K Class
- 12711 Applications Filed
- 11051 Patents Issued To-Date
- 86.95 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 0 Citation Count
- A61K Class
- 0 % this patent is cited more than
- 7 Age
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Dec 19, 2025 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Dec 19, 2029 |
