Human Notch Receptor Mutations and Their Use
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United States of America Patent
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Nov 5, 2015
app pub date -
Nov 14, 2012
filing date -
Nov 16, 2011
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Abstract
The present invention provides the identification and characterization of NOTCH mutations associated with enhanced receptor signaling. The present invention provides methods and kits for using the same. The present invention further provides methods of treating cancer in a patient having a solid tumor, wherein the solid tumor cells comprise an elevated level of NOTCH ICD.
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