PROGRANULIN AS MARKER FOR AUTOIMMUNE DISORDERS
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United States of America Patent
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Nov 5, 2015
app pub date -
Nov 27, 2013
filing date -
Nov 28, 2012
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Abstract
The present invention provides for means and method for the detection and/or the quantification of anti-progranulin-autoantibodies in a biological sample of a subject. The present invention also provides for means and method for the detection and/or the quantification of hyper-phosphorylated progranulin in a biological sample of a subject. The present invention further provides for means and methods for the detection of an aberrant conversion pathway of progranulin into granulines in a biological sample of a subject. In fact, the presence of anti-progranulin-autoantibodies and/or hyper-phosphorylated progranulin and/or an aberrant conversion pathway may be indicative that the subject may be suffering from an autoimmune disorder.
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