SURFACE-MODIFIED IRON OXIDE PARTICLES FOR CANCER ABLATION

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United States of America Patent

APP PUB NO 20150313994A1
SERIAL NO

14427142

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Abstract

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An object of the present invention is to provide surface-modified ferromagnetic iron oxide particles suitable for electromagnetic-induction cancer ablation, which have excellent heat generation properties and also have excellent dispersion stability in a medium for injection. The surface-modified iron oxide particles for cancer ablation of the present invention as a means for achieving the object are characterized in that a block copolymer of polyethylene glycol and polystyrene having a phosphorous acid group in the side chain is bound to the surface of ferromagnetic iron oxide particles having a plate-like shape with a length of 20 to 200 nm and a length-to-thickness ratio of 1.5 to 30 and having magnetic properties such that the coercivity is 30 to 300 Oe, the saturation magnetization is 20 to 80 emu/g, and the squareness ratio of the magnetic hysteresis loop is 0.20 to 0.50.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF TSUKUBA1-1-1 TENNODAI TSUKUBA-SHI IBARAKI 305-8577

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
ASAI, Kei Tsukuba-shi, JP 31 726
KISHIMOTO, Mikio Tsukuba-shi, JP 49 698
KITA, Eiji Tsukuba-shi, JP 4 25
NAGASAKI, Yukio Tsukuba-shi, JP 56 604
ODA, Tatsuya Tsukuba-shi, JP 17 185
OHKOHCHI, Nobuhiro Tsukuba-shi, JP 7 6
YANAGIHARA, Hideto Tsukuba-shi, JP 3 4

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