ARTERIVIRUS
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United States of America Patent
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Issued Date -
Nov 5, 2015
app pub date -
Sep 25, 2013
filing date -
Sep 26, 2012
priority date (Note) -
Abandoned
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Abstract
The present invention relates to replication-competent Arteriviruses having a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2, to their use as a medicament, their use as a vaccine and in prophylaxis, to vaccines comprising such Arteriviruses and to Arteriviral PLP2-ubiquitin complexes.
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