Importance

Loading Importance Indicators...

Abstract

The present application discloses compositions and methods of synthesis and use of ¹⁸F- or ¹⁹F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the ¹⁸F or ¹⁹F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may then be directly or indirectly attached to the targeting molecule. In other embodiments, the ¹⁸F or ¹⁹F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the bifunctional chelating agent bound to ¹⁸F- or ¹⁹F-metal complex may be conjugated to the molecule to be labeled at a reduced temperature, e.g. room temperature.

Loading the Abstract Image...

First Claim