COMPOSITION COMPRISING A SINGLE VARIABLE DOMAIN AND CAMOSTAT MESYLATE (CM)
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United States of America Patent
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Issued Date -
Oct 29, 2015
app pub date -
Aug 21, 2013
filing date -
Aug 21, 2012
priority date (Note) -
Abandoned
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Abstract
The present disclosure provides a means of stabilising a single variable domain, in particular in protease-rich environments such as the stomach and intestine. A composition, in particular a pharmaceutical composition, comprising a single variable domain and camostat mesylate is provided, together with uses of said composition as a medicament and in methods of treatment. Compositions of the disclosure are particularly useful in the topical treatment of gastrointestinal conditions, such as Crohn's Disease or ulcerative colitis, or for direct activity in the gut mucosal immune system.
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