ANALYSIS OF COMPOUNDS FOR PAIN AND SENSORY DISORDERS
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United States of America Patent
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Oct 22, 2015
app pub date -
Apr 21, 2015
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Apr 22, 2014
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The invention generally relates to optical methods for characterizing the effects of compounds on pain and other sensory phenomena. The effect of compounds on pain and other sensory phenomena may be characterized using dorsal root ganglion (DRG) neurons or sensory neurons expressing optogenetic proteins that allow neural activity to be stimulated and detected optically. The invention provides cell-based optical assays for studying the molecular and cellular bases of pain and sensory phenomena and as platforms to screen and validate drugs, e.g., for pre-clinical trials.
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