IMMOBILISED CYCLIN-DEPENDENT KINASE 4 FUSION PROTEINS AND USES THEREOF
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United States of America Patent
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Oct 22, 2015
app pub date -
Sep 5, 2013
filing date -
Sep 5, 2012
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Abstract
The present invention concerns an in vitro assay for determining the activation status of endogenous CDK4 in eukaryotic cells, said assay comprising the steps of: providing eukaryotic cells maintained in a quiescent state, said eukaryotic cells comprising a cyclin D/CDK4 fusion protein, wherein the CDK4 part of the fusion protein is present in a hypophosphorylated form; inducing proliferation of said eukaryotic cells; isolating the cyclin D/CDK4 fusion protein from said eukaryotic cells; and measuring the activation status of said isolated cyclin D/CDK4 fusion protein, thereby determining the activation stats of endogenous CDK4 in said eukaryotic cells.
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