METHODS FOR SELECTING A TREATMENT FOR CANCER
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United States of America Patent
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Oct 22, 2015
app pub date -
Apr 17, 2015
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Apr 17, 2014
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Abstract
Biomarkers predictive of a subject's likelihood of responding to an immunotherapy including blockade of PD-1 inhibitory signaling, and method of use thereof are disclosed. The biomarkers are HIF1-alpha, KDR, CXCL13, and IL7R. Exemplary methods include identifying or selecting a subject who may benefit from treatment with an immunotherapy including blockade of PD-1 signaling, and methods of predicting responsiveness of a subject suffering from cancer to treatment with an immunotherapy including blockade of PD-1 signaling. Preferred immunotherapies and methods of treating subjects with cancer are also provided.
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