DIAROMATIC AMINO ACID SUBSTRATE FOR CATHEPSIN DETECTION
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United States of America Patent
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Issued Date -
Oct 15, 2015
app pub date -
Feb 13, 2013
filing date -
Oct 16, 2012
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Abstract
The present invention relates to a diaromatic amino acid substrate for cathepsin detection. When the substrate used for cathepsin detection is a polymer resulting from the binding of a protease-preferred amino acid and quencher to a diaromatic amino acid, cathepsin can be detected sensitively and accurately by fluorescence because cathepsin causes the protease-preferred amino acid and quencher to dissociate from the diaromatic amino acid, and fluorescence is recovered during this time.
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