SUSTAINED-RELEASE LIPID PRE-CONCENTRATE OF ANIONIC PHARMACOLOGICALLY ACTIVE SUBSTANCES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
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United States of America Patent
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Issued Date -
Oct 15, 2015
app pub date -
Dec 27, 2013
filing date -
Dec 28, 2012
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Abstract
Disclosed is a sustained-release lipid pre-concentrate, comprising: a) at least one liquid crystal former; b) at least one phospholipid; c) at least one liquid crystal hardener; and d) at least one bi- or multivalent metal salt, wherein the sustained-release pre-concentrate exists as a lipid liquid phase in the absence of aqueous fluid and forms into a liquid crystal upon exposure to aqueous fluid. The sustained-release lipid pre-concentrate is configured to enhance the sustained release of anionic pharmacologically active substances through ionic interaction between the bi- or multivalent metal salt and the anionic pharmacologically active substances.
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