COMPOSITION FOR INHIBITING CELLULAR SENESCENCE COMPRISING QUERCETIN-3-O-beta-D-GLUCURONIDE
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United States of America Patent
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Issued Date -
Oct 15, 2015
app pub date -
Sep 5, 2013
filing date -
Sep 6, 2012
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Abandoned
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Abstract
The present invention relates to a composition for inhibiting cellular senescence comprising quercetin-3-O-β-D-glucuronide (Q3GA) as an active ingredient, and provides a composition for inhibiting cellular senescence of fibroblasts or umbilical vein endothelial cells induced by adriamycin or replicative senescence of fibroblasts or umbilical vein endothelial cells. Specifically, the quercetin-3-O-β-D-glucuronide (Q3GA) is characterized by being isolated from Polygoni avicularis herba extract. The composition may be usefully used for treating aging-related diseases, for example, skin aging, rheumatoid arthritis, osteoarthritis, hepatitis, chronically damaged skin tissue, arteriosclerosis, prostatic hyperplasia and liver cancer, by inhibiting a cellular senescence process of human fibroblasts and umbilical vein endothelial cells.
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