DIELECTROPHORETIC DEVICE FOR ANALYSIS OF CELL MECHANICS

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United States of America Patent

APP PUB NO 20150285760A1
SERIAL NO

14642799

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A quadrupole dielectrophoresis device including at least one quadrupole electrode and a matrix patterned with at least one microspot comprising a cell-adherent protein. The quadrupole electrode is positionable to exert a dielectrophoretic force on a cell adhered to the microspot and at least one property of the cell is determined during exertion of the dielectrophoretic force. The quadrupole dielectrophoresis device may include an electric cell-substrate impedance sensing system for measuring cell deformation. A plurality of microspots and quadrupole electrodes may be provided in the device in which case the quadrupole electrodes may be multiplexed to simultaneously exert the same or different forces on different cells adhered to different microspots. Methods of using the quadrupole dielectrophoresis device to analyze cell mechanics are also provided.

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Patent Owner(s)

Patent OwnerAddress
DREXEL UNIVERSITY3141 CHESTNUT STREET PHILADELPHIA PA 19104

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Clyne, Alisa Morss Ardmore, US 5 155
Urbano, Rebecca Philadelphia, US 1 2

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