KETOAMIDE IMMUNOPROTEASOME INHIBITORS
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United States of America Patent
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Issued Date -
Oct 1, 2015
app pub date -
Sep 30, 2013
filing date -
Oct 11, 2012
priority date (Note) -
Abandoned
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Abstract
The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein X, R1, R1′, R2, R2′, R3, R4, R4′ and R5 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease.
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